南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院科研團(tuán)隊(duì)發(fā)現(xiàn)，骨質(zhì)疏松會(huì)加劇認(rèn)知功能衰退，為臨床上治療阿爾茨海默癥等神經(jīng)退行性疾病提供了新思路。相關(guān)論文近期發(fā)表于國(guó)際學(xué)術(shù)期刊《自然·代謝》。

Chinese researchers have discovered that osteoporosis may impair cognitive function, providing a new approach for the clinical treatment of neurodegenerative disorders such as Alzheimer's disease, according to the Nanjing University.
南京大學(xué)表示，我國(guó)學(xué)者發(fā)現(xiàn)骨質(zhì)疏松會(huì)加劇認(rèn)知功能衰退，為臨床上治療阿爾茨海默癥等神經(jīng)退行性疾病提供了新思路。

The discovery, made by a research team from the Nanjing Drum Tower Hospital affiliated with the Medical School of the Nanjing University, has been published in the journal Nature Metabolism.
相關(guān)論文由南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院科研團(tuán)隊(duì)發(fā)表于國(guó)際學(xué)術(shù)期刊《自然·代謝》上。

Previous research has shown that the bones of elderly patients with osteoporosis would release a key osteocyte-derived factor called sclerostin, said Jiang Qing, associate dean at the Medical School of the Nanjing University, adding that in the patient's blood and cerebrospinal fluid, the proportion of sclerostin are high.
南京大學(xué)醫(yī)學(xué)院副院長(zhǎng)蔣青表示，此前有研究顯示，骨質(zhì)疏松的老年患者，其骨骼會(huì)釋放一種骨硬化蛋白。在患者的血液和腦脊液當(dāng)中，骨硬化蛋白的比例均偏高。

The team have conducted more than six years of research on the intrinsic connection between sclerostin and the brain.
骨硬化蛋白和大腦之間有什么內(nèi)在聯(lián)系？對(duì)此團(tuán)隊(duì)開(kāi)展了為期6年多的研究。

Mouse experiments show that sclerostin released by bone cells of aged mice can break through the blood-brain barrier, inhibit the signal transmission of central neurons, damage the plasticity and integrity of neuronal synapses, and cause a decline in the cognitive functions in mice, said Guo Baosheng, associate professor at the medical school.
南京大學(xué)醫(yī)學(xué)院郭保生副教授介紹，小鼠實(shí)驗(yàn)顯示，老年小鼠骨細(xì)胞分泌的骨硬化蛋白可以突破“血腦屏障”，抑制中樞神經(jīng)元的信號(hào)傳遞，損傷神經(jīng)元突觸的可塑性和完整性，從而導(dǎo)致小鼠認(rèn)知功能衰退。

In addition, in the Alzheimer's mouse model experiment, the researchers found that increasing the concentration of sclerostin could accelerate the formation of amyloid plaque and further exacerbate cognitive decline.
另外，在阿爾茨海默癥小鼠模型實(shí)驗(yàn)中，研究人員發(fā)現(xiàn)，增加骨硬化蛋白濃度，淀粉樣斑塊形成速度加快，患病小鼠的認(rèn)知功能也進(jìn)一步惡化。

The research findings demonstrated that Alzheimer's patients with osteoporosis are at an increased risk of cognitive impairment, Guo said.
郭保生說(shuō)，研究結(jié)果表明，患有骨質(zhì)疏松癥的阿爾茨海默癥患者病情進(jìn)一步加重的風(fēng)險(xiǎn)增加。

英文來(lái)源：新華網(wǎng)

編輯：董靜

審核：丹妮 齊磊